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Physicians should be aware of the coincident cause-effect heuristic that may prevent accurate diagnosis of ischemic coronary disease, and the effect of moral judgment (i.

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In young patients, cardiac causes of chest pain can be found in about 16% of cases, noncardiac causes in 68%, and unknown causes in 16%.

Complete remission of a metastatic gastrointestinal stromal tumour with the tyrosine kinase inhibitor imatinib (STI 571).

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Adolescents with ALL appear to be at higher risk than younger children for developing therapy-related complications, including osteonecrosis, deep venous thromboses, and pancreatitis.

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The addition of a hydrophobic group now needed to be countered to sustain the solubility of the substance.

One of these intermediates was also positive in the mouse lymphoma assay.

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The mean plasma concentration increased with increases in the dose, with variability between patients similar to that described in patients with chronic myeloid leukemia.

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Long term high dosage usage of aspirin carries with it a significant risk of serious undesirable side effects, such as kidney problems and gastrointestinal bleeding.

If you have any questions about this, check with your health care professional, especially if your is not well controlled.

Notwithstanding the ethical considerations that should be taken into account in such settings, there is growing concern in the literature over trials that are stopped prematurely, and clinicians should interpret results of this sunitinib malate trial only after understanding the methodologic concerns (see the Discussion section).

This case supports the use of caspofungin as an effective agent against candidal esophagitis.

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Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial.

Thus, possible effects of growth factors should be excluded before diagnosing unclassifiable myelodysplastic syndromes (MDS-U) on the basis of 1% peripheral blasts; ideally, a peripheral smear should be examined at least 1 week off exogenous growth factors.

There is no experience with Gleevec treatment in children under 1 year of age.

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Second primary cancers: New cancers have happened during treatment with IMBRUVICA, including cancers of the skin or other organs.

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Although it is too soon to know how long these responses will last or if patients will be cured with this medication alone, there are many patients who have been treated with imatinib since the first clinical trials in 1999 who still have no detectable cells with the Philadelphia chromosome.

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Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib.

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CMML related to PDGFβR fusion oncogenes.

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Survival benefit with imatinib mesylate versus interferon-alpha-based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia.

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Normal hair growth should return after treatment has ended.

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The patient declined further clinically while on therapy with imatinib.

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Safety and Efficacy of Radiofrequency Ablation for Hepatic Metastases from Gastrointestinal Stromal Tumor.

Added to state that patients with homozygosity for TPMT variants associated with low activity typically are treated with reduced doses of 6-mercaptopurine to avoid excessive toxicity.

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Treatment options include combination chemotherapy with several regimens, the most commonly used being CHOP.

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You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

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The rationale for the use of imatinib in the treatment of DFSP is based on its activity as a selective inhibitor of PDGFB tyrosinase kinase involved in DFSP generation and proliferation.

Patients with B-precursor ALL who were aged 1 to 5 years at diagnosis and did not have any adverse cytogenetic abnormalities ( MLL translocation, BCR-ABL) had a relatively favorable prognosis, without any advantage in outcome with the utilization of HSCT compared with chemotherapy alone.

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There is no consensus on standard antifungal treatment, but amphotericin B, flucytosine, and fluconazole may be used.

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Infants with MLL-rearranged ALL with high MRD at end of consolidation phase are also eligible for allogeneic HSCT in first remission regardless of other presenting features.

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Meier estimated time to first cardiovascular event (CVE) on study.

Predicting toxicities for patients with advanced gastrointestinal stromal tumours treated with imatinib: a study of the European Organisation for Research and Treatment of Cancer, the Italian Sarcoma Group, and the Australasian Gastro-Intestinal Trials Group (EORTC-ISG-AGITG) Eur J Cancer.

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His generalized tonic-clonic seizures and absence seizures have been controlled with carbamazepine for ten years and valproic acid for three years.

Fluorescence quantifications (pixel area) were performed using Image J software (NIH).

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Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML Study IV.

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Propoxyphene is used to relieve mild to moderate pain.

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre, Stop IMatinib (STIM) trial.

The antiproliferative activity for the single agents as well as for the combined treatment was assessed by thymidine incorporation assay.

Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study.

C); a sore throat; cough; chills; difficult, frequent, or painful urination; or other signs of infection during your treatment with paclitaxel injection.

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Nilotinib treatment-associated peripheral artery disease and sudden death: yet another reason to stick to imatinib as front-line therapy for chronic myelogenous leukemia.

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Ask your health care provider any questions you may have about how to use imatinib.

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No effect of imatinib on mast cell density.

Upon arrival in the late evening the patient was afebrile with stable vital signs and appeared to be in significant pain related to the local site of infection.

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Multiple biopsies from the esophagus and stomach during all these occasions were significant for acute and chronic inflammation.

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This enzyme has evolved in mammals to help digest milk when they are infants.

Major molecular responses and undetectable molecular residual disease were also most frequent with imatinib and peginterferon alfa-2a ().

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Subsequent biochemical screenings revealed a set of moderately potentinhibitors, a few of which have comparable potency to Imatinib (an FDA-approved drug for treatment of chronic myeloid leukemia) against Abl.

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The treatment options presently available for chronic phase CML include hydroxyurea, interferon-α, interferon-α plus cytarabine, imatinib, dasatinib, and allogeneic SCT (SCT).

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Plasmapharesis and immunosuppressive therapy, alone and in combination have been reported in the literature as management for these cases.

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Regorafenib for Gastrointestinal Malignancies.

In the setting of spontaneous hypoglycemia, the diagnosis of insulinoma is highly suggested by the finding of elevated plasma insulin and C-peptide levels.

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For example, if aberrations occur in multiple disease targets, determining which of the targets, if any, are of functional relevance to the disease may be impossible within a reasonable timeframe for the patient.

CM-118: Antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers.

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